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Wham is suitable for paired-stop Illumina libraries with conventional insert measurements (~300bp-500bp). Wham integrates mate-pair mapping, break up browse mapping, soft-clipping, different alignment and consensus sequence dependent evidence to predict SV breakpoints with single-nucleotide accuracy. Wham generates a combined pileup (catalog of rea
The comfortable-clipped sequences that overhang the breakpoint are collapsed right into a consensus sequence utilizing a a number of sequence alignment (MSA) offered within the seqAn library [27]. Wham applies 3 filters towards the consensus sequences. Breakpoints are not documented in scenarios exactly where consensus sequences are shorter than te